Phagocyte recognition of apoptotic cells

ثبت نشده
چکیده

57 Hannun, Y. A. and Bell, R. M. (1993) Adv. Lipid. Res. 25, 27-41 Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. and Greenberg, M. (1995) Science 270, 1326-1331 Sawai, H., Okazaki, T., Yamamoto, H., Okano, H., Takeda, Y., Tashima, M., Sawada, H., Okuma, M., Ishikura, H., Umehara, H. and Domae, N. (1995) J. Biol. Chem. 270,27326-27331 Akao, Y., Otsuki, Y., Kataoka, S., Ito, Y. and Tsujimoto, Y. (1994) Cancer Res. 54, 2468-2471 Krajewski, S., Tanaka, S., Takayama, S., Schibler, M. J., Fenton, W. and Redd, J. C. (1993) Cancer Res. 53,4701-4714 Richter, C., Gogvadze, V., Laffranchi, R., Schlapbach, R., Schweizer, M., Suter, M., Walter, P. and Yafee, M. (1995) Biochim. Biophys. Acta

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

During apoptosis, dying cells are swiftly removed by phagocytes. It is not fully understood how apoptotic cells are recognized by phagocytes. Here we report the identification and characterization of the Caenorhabditis elegans ttr-52 gene, which encodes a transthyretin-like protein and is required for efficient cell corpse engulfment. The TTR-52 protein is expressed in, and secreted from, C. el...

متن کامل

Journey to the grave: signaling events regulating removal of apoptotic cells.

Programmed cell death is critical both for organ formation during development and during adult life, when billions of cells must be removed every day. The culmination of the apoptotic process is the specific recognition and engulfment of the apoptotic cell by a phagocyte. A number of recent studies have revealed a series of evolutionarily conserved proteins that link corpse recognition to membr...

متن کامل

“Recruitment Signals” from Apoptotic Cells Invitation to a Quiet Meal

An evolutionarily conserved machinery exists for engulfment of apoptotic cells from worm to mammals. New observations suggest that corpse clearance is tightly linked to apoptosis and that dying cells use both recruitment and eat-me signals for phagocyte attraction and recognition.

متن کامل

Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages.

Introduction Understanding the molecular mechanisms underlying phagocytic clearance of apoptotic cells is an important aim of current cell-death research. Intuitively it is expected that, in the absence of rapid, efficient, and non-phlogistic removal of apoptotic cells and bodies, the process of apoptosis would lose its physiological benefits and, through spillage of intracellular macromolecule...

متن کامل

Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes

Engulfment of apoptotic cells by phagocytes is important throughout development and adult life. When phagocytes engulf apoptotic cells, they increase their cellular contents including cholesterol and phospholipids, but how the phagocytes respond to this increased load is poorly understood. Here, we identify one type of a phagocyte response, wherein the recognition of apoptotic cells triggers en...

متن کامل

Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

Efficient phagocytosis of apoptotic cells is important for normal tissue development, homeostasis, and the resolution of inflammation. Although many receptors have been implicated in the clearance of apoptotic cells, the roles of these receptors in the engulfment process have not been well defined. We developed a novel system to distinguish between receptors involved in tethering of apoptotic c...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009